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Congratulations Stefan, and I agree with others (so well put by Afshin!). It’s a beautifully written paper and great comments from others. </div>
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I wish you and Johan the very best with the resubmission!</div>
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Best wishes,</div>
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Janet</div>
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<span style="line-height:17.25px"><font color="#000000"><font face="garamond, serif" size="2"><span style="font-family:Arial,Helvetica,sans-serif"><b>Janet Jull, OT Reg (Ont), PhD</b></span></font></font></span></div>
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<div id="divRplyFwdMsg" dir="ltr"><font face="Calibri, sans-serif" style="font-size:11pt" color="#000000"><b>From:</b> Futuregen <futuregen-bounces@euro.centre.org> on behalf of Stefan Fors <stefan.fors@ki.se><br>
<b>Sent:</b> November 26, 2021 7:28 AM<br>
<b>To:</b> Afshin Vafaei <vafaei.afshin@gmail.com>; Ricardo Rodrigues <rodrigues@euro.centre.org><br>
<b>Cc:</b> LIST: FutureGEN <futuregen@euro.centre.org><br>
<b>Subject:</b> Re: [Futuregen] Cohort paper [revised version]</font>
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<span style="">Dear all,</span></p>
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<span style=""> </span></p>
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<span style="">Thanks a lot for all of your comments and suggestion. I just submitted the revised manuscript – so let’s keep our fingers crossed!</span></p>
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<span style=""> </span></p>
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<span style="">Have a lovely weekend!</span></p>
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<span style=""> </span></p>
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<span style="">Stefan</span></p>
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<span style=""> </span></p>
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<b><span lang="SV">Från:</span></b><span lang="SV"> Afshin Vafaei <vafaei.afshin@gmail.com>
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<b>Skickat:</b> den 25 november 2021 18:25<br>
<b>Till:</b> Ricardo Rodrigues <rodrigues@euro.centre.org><br>
<b>Kopia:</b> Susan Phillips <phillip@queensu.ca>; Stefan Fors <stefan.fors@ki.se>; LIST: FutureGEN <futuregen@euro.centre.org><br>
<b>Ämne:</b> Re: [Futuregen] Cohort paper [revised version]</span></p>
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<span style="font-family:"Verdana",sans-serif; color:black">Dear Stefan et al.,</span></p>
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<span style="font-family:"Verdana",sans-serif; color:black">I read all your responses, the beautifully composed revised manuscript, and others' comments. All issues have already been covered and I have actually nothing more to add except a few notes that you
 might (or not) want to add to responses. Just to convince the reviewers that their concerns are well understood and addressed.</span></p>
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<span style="font-family:"Verdana",sans-serif; color:black">1) You clarified in the response that you indeed used average marginal estimates but this is not in the porse except when you talk about the 'margin' command of STATA. A good idea to include this in
 the manuscript as well.</span></p>
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<span style="font-family:"Verdana",sans-serif; color:black">2) A very good idea that you removed "robustness of the estimates" from the manuscript, a vague term anyway. You may want to clearly say this in the response and also in the manuscript that  collapsing of
 countries into regions was to increase sample size and hence enhancing statistical power.</span></p>
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<span style="font-family:"Verdana",sans-serif; color:black">3) I hear you and understand the hesitancy for use of an OLS regression for ordinal variables. Generally speaking it is not wrong to do so but interpretation of the coefficients is a little tricky
 because the variable is in fact not continuous. One way to go around this issue is just to mention the results of the sensitivity analysis in one sentence and add (data not shown, available upon request). And tell the reviewer that you did not want to make
 the appendix longer unnecessarily.  </span></p>
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<span style="font-family:"Verdana",sans-serif; color:black">Fantastic work, I am very positive soon you'll have a publication!</span></p>
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<span style="font-family:"Verdana",sans-serif; color:black">Cheers!</span></p>
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<span style="font-family:"Verdana",sans-serif; color:black">Afshin . </span></p>
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On Wed, Nov 24, 2021 at 4:29 PM Ricardo Rodrigues <<a href="mailto:rodrigues@euro.centre.org" target="_blank">rodrigues@euro.centre.org</a>> wrote:</p>
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<span style="font-size:12.0pt; color:black">Dear Stefan, dear Johan,</span></p>
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<span style="font-size:12.0pt; color:black">I read through the changes and replies to the reviewers and I really did not have anything to add, except a couple of suggestions on the "if you really need to" basis below.
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<span style="font-size:12.0pt; color:black">Susan mentioned the need for a reference for the use of the square root equivalization:
</span><span lang="EN-US" style="font-size:12.0pt; color:black">OECD (2011), Divided We Stand – Why Inequality Keeps Rising, Paris.    </span><span lang="EN-US" style="color:black">(<a href="https://can01.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.oecd.org%2Fsocial%2Finequality.htm&data=04%7C01%7Cjanet.jull%40queensu.ca%7Cef46b5d856884a96587908d9b0d85d91%7Cd61ecb3b38b142d582c4efb2838b925c%7C1%7C0%7C637735266801546478%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=qRxJWmcxWBPNHsBYtiTw9FwwYzWQwVbmZFS7kaEoKws%3D&reserved=0" originalsrc="http://www.oecd.org/social/inequality.htm" shash="v7NYDOjhkT6LUXIdN/zHBckS9cILaO4Yu9UByVKf9HtYexhgGnZ3DHy9y5PbT7k/BZIpgYy6jjn8fs0v3arVik0rws8Vvum+2Gs/Los6F24Bv+uHoQnPf6yfkVdJA4m9vEHoY79vYeUeN5IfU9dDiAcnxeVI/T07ZiDq7gJ6XkU=" target="_blank">www.oecd.org/social/inequality.htm</a>
 / <a href="https://can01.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.oecd.org%2Ffr%2Fsocial%2Finegalite.htm&data=04%7C01%7Cjanet.jull%40queensu.ca%7Cef46b5d856884a96587908d9b0d85d91%7Cd61ecb3b38b142d582c4efb2838b925c%7C1%7C0%7C637735266801556426%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=JG2CFAuk0gqF%2BdqY%2Fx5M0NToBfADxdxxENPcNN6goCE%3D&reserved=0" originalsrc="http://www.oecd.org/fr/social/inegalite.htm" shash="fb5unFGDM2ARtFXreLOAWVVq4lOryeXlyLu2RM58mCoq9an/ewVvGkPSVJWafYhu1zr7gx4DQSLVpk0+wvDAQs8TZkxmPaZckKGG23fQAHkBpNvVj9N3VA3Xsfy5Mmfmch7d8U6muXDMS6rSgJlPKVqujMcxZH/pv6YfwOrmaLA=" target="_blank">
www.oecd.org/fr/social/inegalite.htm</a> )</span><span style="font-size:12.0pt; color:black">.</span></p>
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<span style="font-size:12.0pt; color:black">I think the reviewers were quite positive on their assessment of the paper in the first place and your replies are to the point and very good.</span></p>
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<span style="font-size:12.0pt; color:black">You argued well enough for using a dichotomous variable. Reviewer 1 was the one who raised this issue and she/he was also the one who thought the results section was already too long: if you want, you can also mention
 this (text and annexes already too long, as pointed by the said reviewer </span>
<span style="font-size:12.0pt; font-family:"Segoe UI Emoji",sans-serif; color:black">😉</span><span style="font-size:12.0pt; color:black">) to reinforce the use of the dichotomous option only. I would keep the OLS out.</span></p>
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<span style="font-size:12.0pt; color:black">Reviewer 2 mentions the inclusion of complete cases only as a sensitivity analysis - and I think you purposely (and wisely) steered away from opening that can of worms and left this more or less unanswered.
</span><span style="font-size:12.0pt; font-family:"Segoe UI Emoji",sans-serif; color:black">🙂</span><span style="font-size:12.0pt; color:black"> One argument I could think of, for not using only complete cases (apart from exacerbating attrition), is the fact
 that we are interested in cohort differences rather than exclusively on longitudinal developments.</span></p>
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<span style="font-size:12.0pt; color:black">It looks very good!</span></p>
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<span style="font-size:12.0pt; color:black">Best wishes,</span></p>
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<b><span style="color:black">From:</span></b><span style="color:black"> Futuregen <<a href="mailto:futuregen-bounces@euro.centre.org" target="_blank">futuregen-bounces@euro.centre.org</a>> on behalf of Susan Phillips <<a href="mailto:phillip@queensu.ca" target="_blank">phillip@queensu.ca</a>><br>
<b>Sent:</b> Tuesday, November 23, 2021 9:00 PM<br>
<b>To:</b> Stefan Fors <<a href="mailto:stefan.fors@ki.se" target="_blank">stefan.fors@ki.se</a>><br>
<b>Cc:</b> LIST: FutureGEN <<a href="mailto:futuregen@euro.centre.org" target="_blank">futuregen@euro.centre.org</a>><br>
<b>Subject:</b> Re: [Futuregen] Cohort paper [revised version]</span> </p>
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Hi Stefan, </p>
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Your response to reviewers is really clear and covers everything well. I have made a few language edits and a comment or two in the manuscript (attached). I don’t feel like the wisest one to decide about the inclusion of the sensitivity analyses. My sense,
 from what you have written would be to not include.</p>
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Thanks for including me.</p>
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Susan</p>
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On Nov 22, 2021, at 8:59 AM, Stefan Fors <<a href="mailto:stefan.fors@ki.se" target="_blank">stefan.fors@ki.se</a>> wrote:</p>
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<span lang="SV">Dear friends,</span></p>
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I hope all is well with you! We have now tried to address the comments made by the reviewers for the cohort paper. Please find the revised manuscript, tables and figures, appendix, and responses to the reviewers enclosed. For those of you that are co-authors
 on the paper – read the revisions and rebuttal letter and let us know what you think (if you have time). The deadline for submission is Friday, so I would need any comments by Thursday in order to make any changes to the manuscript.</p>
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One thing Johan and I have been discussing is whether we should include figures from our sensitivity analyses using ordinal indicators of ADL and IADL and OLS-regressions (see attached file) in the response to the reviewers (not for publication). On the one
 hand, this would serve as a response to their comments on the dichotomization of the outcomes and potential sensitivity analyses. On the other hand, we may invite a whole new host of comments (“why are these not mentioned in the paper?” “why are you using
 OLS-regressions for ordinal variables?” etc.). So, let us know if you have any opinions on this issue as well.</p>
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All the best,</p>
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Stefan</p>
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<b><span lang="SV" style="font-size:9.0pt; font-family:"Arial",sans-serif">Stefan Fors</span></b><span lang="SV" style="font-size:9.0pt; font-family:"Arial",sans-serif"> | Forskare</span></p>
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<span lang="SV" style="font-size:9.0pt; font-family:"Arial",sans-serif">Aging Research Center | Karolinska Institutet</span></p>
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<span lang="SV" style="font-size:9.0pt; font-family:"Arial",sans-serif">Tomtebodavägen 18A  | 171 65 Solna</span></p>
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<Fors et al.R1.docx><Fors et al_Tables and figures_R1.docx><Fors et al_Supplementary materials_R1.docx><adl iadl OLS regressions.pdf><Reply_reviewers_R1.docx><span style="font-size:12.0pt; font-family:ArialMT">_______________________________________________<br>
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Susan Phillips MD, CCFP</span></p>
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<span style="font-size:12.0pt; font-family:"Arial",sans-serif; color:black">Research Director, Centre for Studies in Primary Care</span></p>
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<span style="font-size:12.0pt; font-family:"Arial",sans-serif; color:black">Rosser Research Chair, Family Medicine</span></p>
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<span style="font-size:12.0pt; font-family:"Arial",sans-serif; color:black">Director QuARMS</span></p>
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<span class="x_s1" style="-webkit-font-kerning: none;"><i>När du skickar e-post till Karolinska Institutet (KI) innebär detta att KI kommer att behandla dina personuppgifter.
</i><a href="https://can01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fki.se%2Fmedarbetare%2Fintegritetsskyddspolicy&data=04%7C01%7Cjanet.jull%40queensu.ca%7Cef46b5d856884a96587908d9b0d85d91%7Cd61ecb3b38b142d582c4efb2838b925c%7C1%7C0%7C637735266801576350%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=3cLDZY1mE2zuudxe39tSg8hbrX6BI7%2BwsscT%2BfAsH1M%3D&reserved=0" originalsrc="https://ki.se/medarbetare/integritetsskyddspolicy" shash="tzHu1M9fAd4yX0UjbwEDRyUbSa9pH9jt7Ff5/f46drGyFGL84Nd+d81pU3uHglMPuYeP9O9Juxxg026Ta1h+qWmSnljnoVuXanuVDtSEVDvv6BCNV4BnfotJb3nDbXF774uCVu3VrYoYh/NOjPfkfA+c1cm3ahET5C82ekDKftk="><span class="x_s2" style="text-decoration: underline; -webkit-font-kerning: none; color: rgb(0, 0, 238);">Här
 finns information om hur KI behandlar personuppgifter</span></a>.<span class="x_Apple-converted-space"> </span></span></p>
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<span class="x_s1" style="-webkit-font-kerning: none;"><i>Sending email to Karolinska Institutet (KI) will result in KI processing your personal data.</i>
<a href="https://can01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fki.se%2Fen%2Fstaff%2Fdata-protection-policy&data=04%7C01%7Cjanet.jull%40queensu.ca%7Cef46b5d856884a96587908d9b0d85d91%7Cd61ecb3b38b142d582c4efb2838b925c%7C1%7C0%7C637735266801586302%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=dn%2Fw4UoCE50hgRdIOqsYQOu%2BJAPFG18%2FP4HijleCMRM%3D&reserved=0" originalsrc="https://ki.se/en/staff/data-protection-policy" shash="gxU6eTa/bZOxeya3f2Wp9e1L2Rx5NJ6jOKgfSyPHwZiv8CYT/97W04f+5hWV2oi+H7ZSXSolh1vQUIgZtULBXI4vpVVwX4dmSurbl8aKsea+mupprL8amzzEja7aKR6dwicpXaxBcwU2ZfT7okW0V5fstPnkerkboutNBCYWBko=">
<span class="x_s2" style="text-decoration: underline; -webkit-font-kerning: none; color: rgb(0, 0, 238);">You can read more about KI’s processing of personal data here</span></a>.<span class="x_Apple-converted-space"> </span></span></p>
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