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<p class="MsoNormal"><span style="mso-fareast-language:EN-US">Dear Stefan and Johan,
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-US">I’ve read through as well – well done! I don’t have anything else to add,
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-US">best regards,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-US">Selma<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-US"><o:p> </o:p></span></p>
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<p class="MsoNormal"><b><span lang="DE">Von:</span></b><span lang="DE"> Futuregen <futuregen-bounces@euro.centre.org>
<b>Im Auftrag von </b>Ricardo Rodrigues<br>
<b>Gesendet:</b> Mittwoch, 24. November 2021 22:28<br>
<b>An:</b> Susan Phillips <phillip@queensu.ca>; Stefan Fors <stefan.fors@ki.se><br>
<b>Cc:</b> LIST: FutureGEN <futuregen@euro.centre.org><br>
<b>Betreff:</b> Re: [Futuregen] Cohort paper [revised version]<o:p></o:p></span></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal"><span style="font-size:12.0pt;color:black">Dear Stefan, dear Johan,<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:12.0pt;color:black">I read through the changes and replies to the reviewers and I really did not have anything to add, except a couple of suggestions on the "if you really need to" basis below.
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<p class="MsoNormal"><span style="font-size:12.0pt;color:black"><o:p> </o:p></span></p>
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<p class="MsoNormal"><span style="font-size:12.0pt;color:black">Susan mentioned the need for a reference for the use of the square root equivalization:
</span><span lang="EN-US" style="font-size:12.0pt;color:black">OECD (2011), Divided We Stand – Why Inequality Keeps Rising, Paris. </span><span lang="EN-US" style="color:black;mso-fareast-language:EN-US">(<a href="http://www.oecd.org/social/inequality.htm">www.oecd.org/social/inequality.htm</a>
/ <a href="http://www.oecd.org/fr/social/inegalite.htm">www.oecd.org/fr/social/inegalite.htm</a> )</span><span style="font-size:12.0pt;color:black">.<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:12.0pt;color:black">I think the reviewers were quite positive on their assessment of the paper in the first place and your replies are to the point and very good.<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:12.0pt;color:black">You argued well enough for using a dichotomous variable. Reviewer 1 was the one who raised this issue and she/he was also the one who thought the results section was already too long: if you want,
you can also mention this (text and annexes already too long, as pointed by the said reviewer
</span><span style="font-size:12.0pt;font-family:"Segoe UI Emoji",sans-serif;color:black">😉</span><span style="font-size:12.0pt;color:black">) to reinforce the use of the dichotomous option only. I would keep the OLS out.<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:12.0pt;color:black">Reviewer 2 mentions the inclusion of complete cases only as a sensitivity analysis - and I think you purposely (and wisely) steered away from opening that can of worms and left this more or less
unanswered. </span><span style="font-size:12.0pt;font-family:"Segoe UI Emoji",sans-serif;color:black">🙂</span><span style="font-size:12.0pt;color:black"> One argument I could think of, for not using only complete cases (apart from exacerbating attrition),
is the fact that we are interested in cohort differences rather than exclusively on longitudinal developments.<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:12.0pt;color:black"><o:p> </o:p></span></p>
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<p class="MsoNormal"><span style="font-size:12.0pt;color:black">It looks very good!<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:12.0pt;color:black">Best wishes,<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:12.0pt;color:black">Ricardo<o:p></o:p></span></p>
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<p class="MsoNormal"><b><span style="color:black">From:</span></b><span style="color:black"> Futuregen <<a href="mailto:futuregen-bounces@euro.centre.org">futuregen-bounces@euro.centre.org</a>> on behalf of Susan Phillips <<a href="mailto:phillip@queensu.ca">phillip@queensu.ca</a>><br>
<b>Sent:</b> Tuesday, November 23, 2021 9:00 PM<br>
<b>To:</b> Stefan Fors <<a href="mailto:stefan.fors@ki.se">stefan.fors@ki.se</a>><br>
<b>Cc:</b> LIST: FutureGEN <<a href="mailto:futuregen@euro.centre.org">futuregen@euro.centre.org</a>><br>
<b>Subject:</b> Re: [Futuregen] Cohort paper [revised version]</span> <o:p></o:p></p>
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<p class="MsoNormal"> <o:p></o:p></p>
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<p class="MsoNormal">Hi Stefan, <o:p></o:p></p>
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<p class="MsoNormal">Your response to reviewers is really clear and covers everything well. I have made a few language edits and a comment or two in the manuscript (attached). I don’t feel like the wisest one to decide about the inclusion of the sensitivity
analyses. My sense, from what you have written would be to not include.<o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal">Thanks for including me.<o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal">Susan<o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal">On Nov 22, 2021, at 8:59 AM, Stefan Fors <<a href="mailto:stefan.fors@ki.se">stefan.fors@ki.se</a>> wrote:<o:p></o:p></p>
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<p class="MsoNormal"><span lang="SV">Dear friends,</span><o:p></o:p></p>
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<p class="MsoNormal"><span lang="SV"> </span><o:p></o:p></p>
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<p class="MsoNormal">I hope all is well with you! We have now tried to address the comments made by the reviewers for the cohort paper. Please find the revised manuscript, tables and figures, appendix, and responses to the reviewers enclosed. For those of you
that are co-authors on the paper – read the revisions and rebuttal letter and let us know what you think (if you have time). The deadline for submission is Friday, so I would need any comments by Thursday in order to make any changes to the manuscript.<o:p></o:p></p>
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<p class="MsoNormal"> <o:p></o:p></p>
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<p class="MsoNormal">One thing Johan and I have been discussing is whether we should include figures from our sensitivity analyses using ordinal indicators of ADL and IADL and OLS-regressions (see attached file) in the response to the reviewers (not for publication).
On the one hand, this would serve as a response to their comments on the dichotomization of the outcomes and potential sensitivity analyses. On the other hand, we may invite a whole new host of comments (“why are these not mentioned in the paper?” “why are
you using OLS-regressions for ordinal variables?” etc.). So, let us know if you have any opinions on this issue as well.<o:p></o:p></p>
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<p class="MsoNormal"> <o:p></o:p></p>
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<p class="MsoNormal">All the best,<o:p></o:p></p>
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<p class="MsoNormal"> <o:p></o:p></p>
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<p class="MsoNormal">Stefan<o:p></o:p></p>
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<p class="MsoNormal"> <o:p></o:p></p>
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<p class="MsoNormal"><b><span lang="SV" style="font-size:9.0pt;font-family:"Arial",sans-serif">Stefan Fors</span></b><span class="xxapple-converted-space"><span lang="SV" style="font-size:9.0pt;font-family:"Arial",sans-serif"> </span></span><span lang="SV" style="font-size:9.0pt;font-family:"Arial",sans-serif">|
Forskare</span><o:p></o:p></p>
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<p class="MsoNormal"><span lang="SV"> </span><o:p></o:p></p>
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<p class="MsoNormal"><span lang="SV" style="font-size:9.0pt;font-family:"Arial",sans-serif">Aging Research Center | Karolinska Institutet</span><o:p></o:p></p>
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<p class="MsoNormal"><span lang="SV" style="font-size:9.0pt;font-family:"Arial",sans-serif">Widerströmska huset, plan 9</span><o:p></o:p></p>
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<p class="MsoNormal"><span lang="SV" style="font-size:9.0pt;font-family:"Arial",sans-serif">Tomtebodavägen 18A | 171 65 Solna</span><o:p></o:p></p>
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<p class="MsoNormal"><span lang="SV" style="font-size:9.0pt;font-family:"Arial",sans-serif">+46 (0) 703 368 588<br>
<u><span style="color:#993366"><a href="mailto:stefan.fors@ki.se"><span style="color:#0563C1">stefan.fors@ki.se</span></a></span></u><span class="xxapple-converted-space"> </span>|<span class="xxapple-converted-space"> </span><u><span style="color:#993366"><a href="https://can01.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.ki.se%2Fnvs&data=04%7C01%7Cphillip%40queensu.ca%7C6d67746ff5e541895e6a08d9adc07298%7Cd61ecb3b38b142d582c4efb2838b925c%7C1%7C0%7C637731867070702642%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=jm2vg%2BUgZSGNDug4mujBhSRctbUPP83GYeGq9KIeWGk%3D&reserved=0"><span style="color:#0563C1">www.ki.se/nvs</span></a></span></u><span class="xxapple-converted-space"> </span>|<span class="xxapple-converted-space"> </span><u><span style="color:#993366"><a href="https://can01.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.ki-su-arc.se%2F&data=04%7C01%7Cphillip%40queensu.ca%7C6d67746ff5e541895e6a08d9adc07298%7Cd61ecb3b38b142d582c4efb2838b925c%7C1%7C0%7C637731867070712606%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=s2b229Ynz%2Fv4uZWXf3Igw%2Fh0KKs27SGq5809YAAjxIw%3D&reserved=0"><span style="color:#993366">www.ki-su-arc.se</span></a></span></u></span><o:p></o:p></p>
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<p class="MsoNormal"><span lang="SV" style="font-size:9.0pt;font-family:"Arial",sans-serif">______________________________________</span><o:p></o:p></p>
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<p class="MsoNormal"><span lang="SV" style="font-size:9.0pt;font-family:"Arial",sans-serif">Karolinska Institutet - ett medicinskt universitet</span><o:p></o:p></p>
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<p class="MsoNormal"><Fors et al.R1.docx><Fors et al_Tables and figures_R1.docx><Fors et al_Supplementary materials_R1.docx><adl iadl OLS regressions.pdf><Reply_reviewers_R1.docx><span style="font-size:12.0pt;font-family:"ArialMT",serif">_______________________________________________<br>
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Susan Phillips MD, CCFP<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:black">Research Director, Centre for Studies in Primary Care<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:black">Rosser Research Chair, Family Medicine<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:black">Director QuARMS<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:black">Queen’s U.<o:p></o:p></span></p>
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