<div dir="ltr"><div dir="ltr"><font face="verdana, sans-serif" color="#000000">Dear Stefan et al.,</font></div><div dir="ltr"><font face="verdana, sans-serif" color="#000000"><br></font></div><div dir="ltr"><font face="verdana, sans-serif" color="#000000">I read all your responses, the beautifully composed revised manuscript, and others' comments. All issues have already been covered and I have actually nothing more to add except a few notes that you might (or not) want to add to responses. Just to convince the reviewers that their concerns are well understood and addressed.</font></div><div dir="ltr"><font face="verdana, sans-serif" color="#000000"><br></font></div><div dir="ltr"><font face="verdana, sans-serif" color="#000000">1) You clarified in the response that you indeed used average marginal estimates but this is not in the porse except when you talk about the 'margin' command of STATA. A good idea to include this in the manuscript as well.</font><div><span lang="EN-GB" style=""><font face="verdana, sans-serif" color="#000000"><br></font></span></div><div><font face="verdana, sans-serif" color="#000000"><span lang="EN-GB" style="">2) A very good idea that you removed </span>"robustness of the estimates" from the manuscript, a vague term anyway. You may want to clearly say this in the response and also in the manuscript that collapsing of countries into regions was to increase sample size and hence enhancing statistical power.</font></div><div><font face="verdana, sans-serif" color="#000000"><br></font></div><div><font face="verdana, sans-serif" color="#000000">3) I hear you and understand the hesitancy for use of an OLS regression for ordinal variables. Generally speaking it is not wrong to do so but interpretation of the coefficients is a little tricky because the variable is in fact not continuous. One way to go around this issue is just to mention the results of the sensitivity analysis in one sentence and add (data not shown, available upon request). And tell the reviewer that you did not want to make the appendix longer unnecessarily. </font></div><div><font face="verdana, sans-serif" color="#000000"><br></font></div><div><font face="verdana, sans-serif" color="#000000">Fantastic work, I am very positive soon you'll have a publication!</font></div><div><font face="verdana, sans-serif" color="#000000"><br></font></div><div><font face="verdana, sans-serif" color="#000000">Cheers!</font></div><div><font face="verdana, sans-serif" color="#000000"><br></font></div><div><font face="verdana, sans-serif" style="" color="#000000">Afshin . </font></div></div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">On Wed, Nov 24, 2021 at 4:29 PM Ricardo Rodrigues <<a href="mailto:rodrigues@euro.centre.org" target="_blank">rodrigues@euro.centre.org</a>> wrote:<br></div><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">
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Dear Stefan, dear Johan,<br>
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I read through the changes and replies to the reviewers and I really did not have anything to add, except a couple of suggestions on the "if you really need to" basis below.
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Susan mentioned the need for a reference for the use of the square root equivalization:
<span lang="EN-US">OECD (2011), Divided We Stand – Why Inequality Keeps Rising, Paris.<span>
</span><u></u> <u></u></span><span style="font-size:11pt;line-height:107%;font-family:Calibri,sans-serif" lang="EN-US">(<a href="http://www.oecd.org/social/inequality.htm" target="_blank">www.oecd.org/social/inequality.htm</a>
/ <a href="http://www.oecd.org/fr/social/inegalite.htm" target="_blank">www.oecd.org/fr/social/inegalite.htm</a> )</span>.</div>
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I think the reviewers were quite positive on their assessment of the paper in the first place and your replies are to the point and very good.</div>
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You argued well enough for using a dichotomous variable. Reviewer 1 was the one who raised this issue and she/he was also the one who thought the results section was already too long: if you want, you can also mention this (text and annexes already too long,
as pointed by the said reviewer 😉) to reinforce the use of the dichotomous option only. I would keep the OLS out.</div>
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Reviewer 2 mentions the inclusion of complete cases only as a sensitivity analysis - and I think you purposely (and wisely) steered away from opening that can of worms and left this more or less unanswered.
<span id="m_4232159156635089619m_5208129043305286915m_7326301901664493893gmail-m_-305765803419941517gmail-m_5847760962943159424gmail-m_1599448604284149084🙂">🙂</span> One argument I could think of, for not using only complete cases (apart from exacerbating attrition), is the fact that we are interested in cohort differences rather than exclusively on longitudinal developments.<br>
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<div id="m_4232159156635089619m_5208129043305286915m_7326301901664493893gmail-m_-305765803419941517gmail-m_5847760962943159424gmail-m_1599448604284149084appendonsend"></div>
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It looks very good!</div>
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Best wishes,</div>
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Ricardo<br>
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<div id="m_4232159156635089619m_5208129043305286915m_7326301901664493893gmail-m_-305765803419941517gmail-m_5847760962943159424gmail-m_1599448604284149084divRplyFwdMsg" dir="ltr"><font style="font-size:11pt" face="Calibri, sans-serif" color="#000000"><b>From:</b> Futuregen <<a href="mailto:futuregen-bounces@euro.centre.org" target="_blank">futuregen-bounces@euro.centre.org</a>> on behalf of Susan Phillips <<a href="mailto:phillip@queensu.ca" target="_blank">phillip@queensu.ca</a>><br>
<b>Sent:</b> Tuesday, November 23, 2021 9:00 PM<br>
<b>To:</b> Stefan Fors <<a href="mailto:stefan.fors@ki.se" target="_blank">stefan.fors@ki.se</a>><br>
<b>Cc:</b> LIST: FutureGEN <<a href="mailto:futuregen@euro.centre.org" target="_blank">futuregen@euro.centre.org</a>><br>
<b>Subject:</b> Re: [Futuregen] Cohort paper [revised version]</font>
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<div>Hi Stefan,
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<div>Your response to reviewers is really clear and covers everything well. I have made a few language edits and a comment or two in the manuscript (attached). I don’t feel like the wisest one to decide about the inclusion of the sensitivity analyses.
My sense, from what you have written would be to not include.</div>
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<div>Thanks for including me.</div>
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<div>Susan</div>
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<div>On Nov 22, 2021, at 8:59 AM, Stefan Fors <<a href="mailto:stefan.fors@ki.se" target="_blank">stefan.fors@ki.se</a>> wrote:</div>
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<span lang="SV">Dear friends,</span></div>
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<span lang="SV"> </span></div>
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I hope all is well with you! We have now tried to address the comments made by the reviewers for the cohort paper. Please find the revised manuscript, tables and figures, appendix, and responses to the reviewers enclosed. For those of you that are co-authors
on the paper – read the revisions and rebuttal letter and let us know what you think (if you have time). The deadline for submission is Friday, so I would need any comments by Thursday in order to make any changes to the manuscript.</div>
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One thing Johan and I have been discussing is whether we should include figures from our sensitivity analyses using ordinal indicators of ADL and IADL and OLS-regressions (see attached file) in the response to the reviewers (not for publication). On the one
hand, this would serve as a response to their comments on the dichotomization of the outcomes and potential sensitivity analyses. On the other hand, we may invite a whole new host of comments (“why are these not mentioned in the paper?” “why are you using
OLS-regressions for ordinal variables?” etc.). So, let us know if you have any opinions on this issue as well.</div>
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All the best,</div>
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Stefan</div>
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<a href="mailto:Futuregen@euro.centre.org" style="font-family:ArialMT;font-size:16px;font-style:normal;font-variant-caps:normal;font-weight:normal;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px" target="_blank">Futuregen@euro.centre.org</a><br style="font-family:ArialMT;font-size:16px;font-style:normal;font-variant-caps:normal;font-weight:normal;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px">
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Susan Phillips MD, CCFP</div>
<div>Research Director, Centre for Studies in Primary Care</div>
<div>Rosser Research Chair, Family Medicine</div>
<div>Director QuARMS</div>
<div>Queen’s U.</div>
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